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Enzyme found in humans
RPS6KA2 Identifiers Aliases RPS6KA2 , HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2External IDs OMIM : 601685 ; MGI : 1342290 ; HomoloGene : 100680 ; GeneCards : RPS6KA2 ; OMA :RPS6KA2 - orthologs Wikidata
Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene .[5] [6]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases . This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen -activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation . Alternate transcriptional splice variants, encoding different isoforms , have been characterized.[6]
Interactions [ edit ]
RPS6KA2 has been shown to interact with MAPK3 [7] [8] and MAPK1 .[7] [8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000071242 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023809 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol . 266 (2 Pt 1): C351–9. doi :10.1152/ajpcell.1994.266.2.C351 . PMID 8141249 .
^ a b "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2" .
^ a b Roux PP, Richards Stephanie A, Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity" . Mol. Cell. Biol . 23 (14). United States: 4796–804. doi :10.1128/MCB.23.14.4796-4804.2003 . ISSN 0270-7306 . PMC 162206 . PMID 12832467 .
^ a b Zhao Y, Bjorbaek C, Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47). UNITED STATES: 29773–9. doi :10.1074/jbc.271.47.29773 . ISSN 0021-9258 . PMID 8939914 .
Further reading [ edit ]
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect . 24 (3): 317–20. doi :10.1016/S0163-4453(05)80037-4 . PMID 1602151 .
Zhao Y, Bjørbaek C, Weremowicz S, et al. (1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation" . Mol. Cell. Biol . 15 (8): 4353–63. doi :10.1128/MCB.15.8.4353 . PMC 230675 . PMID 7623830 .
Wong EV, Schaefer AW, Landreth G, Lemmon V (1996). "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1" . J. Biol. Chem . 271 (30): 18217–23. doi :10.1074/jbc.271.30.18217 . PMID 8663493 .
Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science . 273 (5277): 959–63. Bibcode :1996Sci...273..959X . doi :10.1126/science.273.5277.959 . PMID 8688081 . S2CID 22226803 .
Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases" . J. Biol. Chem . 271 (47): 29773–9. doi :10.1074/jbc.271.47.29773 . PMID 8939914 .
Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates" . EMBO J . 16 (8): 1921–33. doi :10.1093/emboj/16.8.1921 . PMC 1169795 . PMID 9155018 .
del Peso L, González-García M, Page C, et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science . 278 (5338): 687–9. Bibcode :1997Sci...278..687D . doi :10.1126/science.278.5338.687 . PMID 9381178 .
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB" . EMBO J . 17 (15): 4426–41. doi :10.1093/emboj/17.15.4426 . PMC 1170775 . PMID 9687510 .
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB" . J. Biol. Chem . 273 (49): 32377–9. doi :10.1074/jbc.273.49.32377 . PMID 9829964 .
Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo" . J. Biol. Chem . 274 (5): 2893–8. doi :10.1074/jbc.274.5.2893 . PMID 9915826 .
Jensen CJ, Buch MB, Krag TO, et al. (1999). "90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1" . J. Biol. Chem . 274 (38): 27168–76. doi :10.1074/jbc.274.38.27168 . PMID 10480933 .
Schimenti JC (2000). "ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus". Mamm. Genome . 10 (10): 969–76. doi :10.1007/s003359901142 . PMID 10501965 . S2CID 23157540 .
Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase" . J. Biol. Chem . 274 (43): 31108–13. doi :10.1074/jbc.274.43.31108 . PMID 10521512 .
Tan Y, Demeter MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival" . J. Biol. Chem . 275 (33): 25865–9. doi :10.1074/jbc.M004199200 . PMID 10837486 .
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155" . Biochem. J . 349 (Pt 2): 547–57. doi :10.1042/0264-6021:3490547 . PMC 1221178 . PMID 10880354 .
Datta SR, Katsov A, Hu L, et al. (2000). "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation" . Mol. Cell . 6 (1): 41–51. doi :10.1016/S1097-2765(00)00006-X . PMID 10949026 .
Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene . 19 (54): 6324–33. doi :10.1038/sj.onc.1204007 . PMID 11175347 . S2CID 20150481 .
Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit". Cell. Signal . 13 (9): 653–64. doi :10.1016/S0898-6568(01)00185-1 . PMID 11495723 .
Schinelli S, Zanassi P, Paolillo M, et al. (2001). "Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways" . J. Neurosci . 21 (22): 8842–53. doi :10.1523/JNEUROSCI.21-22-08842.2001 . PMC 6762276 . PMID 11698596 .
Activity Regulation Classification Kinetics Types